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M9490670.TXT
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1994-09-24
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38 lines
Document 0670
DOCN M9490670
TI [Childhood visceral leishmaniasis in the Alpes-Maritimes from 1985 to
1992]
DT 9411
AU Marty P; Leger I; Albertini M; Gari-Toussaint M; Tommasi C; Manassero J;
Le Fichoux Y; Mariani R; Clinique Medicale Infantile, Hopital de Cimiez,
Nice.
SO Bull Soc Pathol Exot. 1994;87(2):105-9. Unique Identifier : AIDSLINE
MED/94339723
AB Here, we present an analysis of clinical and biological data from 15
infantile visceral leishmaniasis recorded between 1985 and 1992 in the
French department of Alpes-Maritimes. The association of fever,
splenomegalia, tricytopenia remains the most constant and predictive of
diagnosis (90% of cases). Bone marrow smear affirms diagnosis in 93% of
cases. Leishmania infantum MON-1 is the causative agent. Except for one
case of advanced stade with severe hepatic lesions and one case of
clinical resistance to Glucantime, prognosis is favourable under
treatment with antimony derivatives. The long term results for children
considered cured after initial treatment is satisfactory. In the
department, the number of cases of combined ages has increased regularly
since 1985. The number of infantile forms has increased but now
represents nevertheless no more than 28% of total cases. On the other
hand, cases are increasing in adults and 40% of those adult cases are in
HIV positive patients.
DE Adolescence Adult Animal Antimony/ADMINISTRATION & DOSAGE/THERAPEUTIC
USE Antiprotozoal Agents/ADMINISTRATION & DOSAGE/THERAPEUTIC USE Bone
Marrow/PARASITOLOGY Case Report Child Child, Preschool English
Abstract Female France/EPIDEMIOLOGY Human Infant *Leishmania
infantum/ISOLATION & PURIF Leishmaniasis, Visceral/DIAGNOSIS/DRUG
THERAPY/*EPIDEMIOLOGY/ PHYSIOPATHOLOGY Male Meglumine/ADMINISTRATION
& DOSAGE/THERAPEUTIC USE Organometallic Compounds/ADMINISTRATION &
DOSAGE/THERAPEUTIC USE Retrospective Studies JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).